The United States and Israel targeted Iran in coordinated attacks over the weekend that killed Supreme Leader Ayatollah Ali Khamenei and dozens of other senior figures and kicked off a furious Iranian response that was expanding into a wider regional war. Allies of the U.S. pledged to help stop Iran’s missile and drone strikes. The Lebanese militant group Hezbollah claimed strikes on Israel for the first time in more than a year, and Israel fired back. The first U.S. military deaths have been reported. Other deaths have been confirmed in Israel and Gulf nations, while Iran has said several hundred people have been killed there. With Khamenei’s death, the Islamic Republic must now choose a supreme leader for the first time since 1989. U.S. President Donald Trump has urged Iranians to seize the moment and overthrow the theocracy that cracked down on nationwide protests earlier this year. There was no sign that was happening. Around the world, some protested. Others cheered. The attacks came two days after the latest U.S.-Iran talks aimed at putting controls on Tehran’s nuclear program