DUBAI, United Arab Emirates — Israel killed two senior Iranian security officials in a major blow to the Islamic Republic’s leadership as it faces its greatest test in decades, and Iran responded Wednesday with renewed missile and drone attacks on its Gulf Arab neighbors and Israel. Ali Larijani, secretary of Iran’s Supreme National Security Council, was considered one of the most powerful figures in the country since Supreme Leader Ayatollah Ali Khamenei was killed in an airstrike on the first day of the war. Gen. Gholam Reza Soleimani was the head of the Revolutionary Guard’s all-volunteer Basij. Iran confirmed the killings of both men, who were key to Iran’s violent crackdown on protests in January that challenged the theocracy’s 47-year rule. Israel’s military said Iran launched another round of missiles toward Israel on Wednesday. Sirens sounded across central Israel and loud booms were heard in Tel Aviv as the war showed no signs of abating. With concerns growing about a global energy crisis, an Iranian official said Tehran had no intention of relinquishing its tight